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**Global
Least Squares Analysis
(GLSA) library is a PC software library that performs simultaneous non-linear
least squares parameters optimization of several model functions. Each model
function may have its own set of points to be fitted. This type of analysis is
called Global Analysis especially in conjunction to Fluorescence Kinetics Analysis.
The standard, one model, one data set problem is just a particular case of GLSA problem.
GLSA problem is generally characterized by a large number
of parameters being optimized and a large number of local minima to be caught
in. GLSA library implements an Alango proprietary algorithm for non-linear least squares optimization. The algorithm was designed for complex non-linear least
squares problems with many parameters, ill-conditioning and multiple local
minima. It greatly reduces probability of falling into a local minimum
when initial values of optimized parameters are far from optimal. Obligatory
for GLSA problems, such robustness significantly simplifies the choice of initial
values for the standard one model, one data set problems.
GLSA library is organized as a set of simple API functions
written in an object-oriented manner. It is easily integrated into other software
with just a few lines of code. There are APIs for creating/destroying a GLSA
computational object, defining model functions, linking different parameters
together and fixing specific parameters.
The library provides capabilities for callbacks during computational
process so that the optimization may be easily and effectively visualized and
interrupted if necessary. The library is written in ANSI C programming language
and may be easily ported to other general purpose or DSP based computational
platforms. The library may be licensed to commercial software developers for
integration into proprietary software as well as to end-users writing their
own data analysis software.**

** GLSA library
is used in our Dynals
and FAST products guaranteeing their stability and ease of use.**

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